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09:30
Session I
REDOX & ENERGY METABOLISMChairs: Rodrigue Rossignol (MRGM, Bordeaux) & Sophie Vasseur (CRCM, Marseille)
09:30 Symposium Welcome,
Rodrigue Rossignol (MRGM, Bordeaux)
09:40 Keynote lecture
Mitochondrial redox signaling and drug modulation,
Mike Murphy (Cambridge, United Kingdom)
10:20 Lecture
xCT-based inducers of ferroptosis in the treatment of pancreatic ductal adenocarcinoma – opportunities and challenges,
Milica Vucetic (Centre Scientifique de Monaco)
10:40 Selected talk
Exploiting a redox bottleneck to combat drug tolerance in pancreatic cancer, Holly Brunton (CRUK Beatson, United Kingdom)
10:55 Industry Talk
The next generation of immunotherapies requires a new generation of cell analysis tools, Pascale Daou (Cell Analysis, Agilent Technologies)
11:05 Lecture
Preventing cancer metastasis with superoxide scavengers,
Pierre Sonveaux (UC Louvain, Belgium)
11:25 Selected talk
Targeting mitochondrial and redox metabolism to prevent relapse in pancreatic cancer, Nadine Abdel Hadi (CRCM, Marseille, France)
11:40 Industry Talk
Nanolive microscopes deliver a complete solution for label-free high resolution live cell imaging and quantitative analysis,
Adrian Baumann (Nanolive)
12:10 - 14:00
BROWSE THE E-POSTERS AND CHAT12:30
MEET THE EDITORSChairs: Laurent Le Cam (IRCM, Montpellier) & Rodrigue Rossignol (MRGM, Bordeaux)
Cancer Cell, Nelly Baratta
14:00
Session II
REDOX & HYPOXIAChairs: Nathalie Mazure (C3M, Nice) & Marija Vlaski-Lafarge (EFS/ BMGIC, Bordeaux)
14:00 Welcome talk, Nathalie Mazure (C3M, Nice)
14:05 Nobel lecture: Understanding cellular oxygen sensing mechanisms: implications for cancer, Sir Peter J. Ratcliffe (Oxford, United Kingdom)
15:05 Lecture: Breaking the hypoxic barrier to PARP inhibitors, Amato Giaccia (Oxford, United Kingdom)
15:45 Industry Symposium
Hypoxia live session, Petra Miikkulainen (Baker Ruskinn) & Gaëtan Podeur (Alliance Bio Expertise)
16:15 Industry talk
Innovative tools for monitoring mitochondrial events in vitro,
Frédéric Samazan (Tebu-Bio)
16:25 Selected talk
HIF1A promotes prostatic intraepithelial neoplasia evolution,
Mohamed Abu El Maaty (IGBMC, Illkirch, France)
16:40 Lecture: The dual metabolic control of stem cell niche: an energy restriction model for the selection of chronicmyeloid leukaemia cells sensitive or resistant to therapy, Persio Dello Sbarba (Firenze, Italy)
17:10
BROWSE THE E-POSTERS AND CHAT
09:30
Session III
METABOLIC PROFILING AND EPIGENETIC CONTROLChairs: Laurent Le Cam (IRCM, Montpellier) & Stéphane Rocchi (C3M, Nice)
09:30 Welcome talk, Laurent Le Cam (IRCM, Montpellier)
09:35 Keynote lecture
Novel chromatin based mechanisms, Robert Schneider (Helmholtz Munich, Germany)
10:15 Lecture: Epigenetic reprogramming in SDH-deficient cancers,
Judith Favier (Cardiovascular Research Center HEGP, Paris, France)
10:45 Selected talk
Methylglyoxal, a glycolysis by-product, epigenetically silences tumor suppressor genes in triple negative breast cancer, Assia Tiamiou (University of Liège, Belgium)
11:00 Lecture: SCENITH: functional profiling energy metabolism and epigenetics in human samples by Flow cytometry, Rafael Jose Argüello (CIML, Marseille, France)
11:25 Industry Talk
NextGen-O2k and Bioenergetics Communications, Erich Gnaiger (Oroboros Instruments innovations)
11:40 Selected talk
Translatome-based classification reveals a dual metabolic dependency
of a new TUMC subtype of pancreatic cancer, Yvan Martineau (CRCT, Toulouse, France)
11:55 Selected talk
Interaction of LncRNA LENOX with the GTPase RAP2C promotes
oxidative phosphorylation, melanoma cell survival
and resistance to BRAF inhibition,
Giovanni Gambi (IGBMC, Illkirch, France)
12:10 Short presentation of SFC, Julie Pannequin (SFC)
12:15 - 14:00
BROWSE THE E-POSTERS AND CHAT14:00
Session IV
SIGNALING, FUELING & METABOLISM IN CANCERChairs: Frédéric Bost (C3M, Nice) & Jean-Emmanuel Sarry (CRCT, Toulouse)
14:00 Welcome talk,
Jean-Emmanuel Sarry (CRCT, Toulouse)
14:05 Metabolic control of immunity by the hexosamine biosynthetic pathway and O-GlcNacylation, Maya Saleh
Oncoimmunology Research, ImmunoConcEpT Laboratories, Department of Life Sciences and Health, The University of Bordeaux, France)
14:35 Lecture: Dietary fatty acids and the regulation of glycolysis, Alicia Kowaltowski (São Paulo, Brazil)
14:55 Selected talk
Role of the transcription factor to liver carcinogenesis,
Emmanuel Benichou (Institut Cochin, Paris, France)
15:10 Industry talk
Analysis of rates of cellular bioenergetics pathways and applications in studying metabolic reprogramming of cancer cells,
Barry Bochner (Biolog Inc)
15:40 Lecture
Autophagic and primary cilium machineries crosstalk in mechanical stress sensing: molecular and functional aspects,
Etienne Morel (Institut Necker Enfants Malades, Paris, France)
16:00 Selected talk
PPARD integrates microenvironmental signals to activate
a pro-metastatic metabolic program in pancreatic cancer, Beatriz Parejo-Alonso (IIS Aragón, Zaragoza, Spain)
16:15 Keynote lecture
Dietary modulation and cancer therapy,
Karen Vousden (Crick Institute, United Kingdom)
17:20 Best talks & e-poster awards
09h00
Session V
(GRAND PUBLIC)CANCER ET NUTRITIONEn partenariat avec le réseau NACRe
Modérateurs : Alice Carrier (CRCM, Marseille), Jean-Ehrland Ricci (C3M, Nice) & Rodrigue Rossignol (MRGM, Bordeaux)
Avec la participation des comédiens Morgane Clémenceau et Philippe Souque
09h00 • Mot de bienvenue et présentation du réseau NACRe Nathalie Caplet (BRIO, Bordeaux) et Bernard Srour (Coordinateur du réseau NACRe)
09h15 • Présentation du réseau et des conclusions du rapport INCa 2020, Bernard Srour (Coordinateur du réseau NACRe)
09h40 • Régimes restrictifs, thérapies ciblées et immunothérapie, Bruno Raynard (Gustave Roussy, Villejuif)
10h05 • Vrai et faux sur nutrition et cancer, Vanessa Cottet (LNC Dijon)
10h30 • Pause
10h40 • Nutrition clinique au sein des soins de support : dépistage de la dénutrition (cachexie) et optimisation des organisations, Pierre Senesse (Institut du Cancer de Montpellier)
11h05 • Oncogériatrie : accompagner les personnes âgées pendant le diagnostic et le traitement d’un cancer, Isabelle Bourdel-Marchasson (CHU Bordeaux)
11h30 Table ronde
Modérateurs : Alice Carrier (CRCM, Marseille) et Jean-Ehrland Ricci (C3M, Nice)
Présentation du collectif ASPERON & Co (Associations et Patients Engagés pour la Recherche en Oncologie & Communauté professionnelle), Nathalie Caplet (BRIO, Bordeaux)
Questions soulevées par le collectif & questions générales du chat,
tous les intervenants
12h00 Conclusion, Rodrigue Rossignol (MRGM, Bordeaux)
12h05 Fin de la réunion
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